阿尔茨海默病(AD)是一种以进行性认知功能减退为特征的神经变性疾病,虽然已有多种药物被批准用于AD的治疗,但疗效有限。目前,一些针对AD发病机制的药物正在研究之中,主要是针对β-淀粉样蛋白致病性及易损神经元变性,还有一些针对载脂蛋白E和Tau蛋白致病性的不太成熟的治疗措施。文章就AD的治疗前景及存在的问题作一综述。 Alzheimer's disease(AD) is a neurodegenerative dementia characterized as progressive cognitive impairment.Despite approval of several drugs for AD,the curative effect was limited.Fortunately,many new therapies directly targeting the mechanisms underlying AD are now in the pipeline.The investigative AD therapies are to block pathogenic β-amyloid protein and to rescue vulnerable neurons from degeneration.Some less mature strategies aim to prevent the pathogenic effects of apolipoprotein E and the microtubule-... 文献名称 阿尔茨海默病的治疗 Article Name 英文(英语)翻译 Treatment of Alzheimer's disease; 作者 孙治坤; 陈生弟; Author SUN Zhi-kun reviewer CHEN Sheng-di reviser(Department of Neurology;Institute of Neurology;The Center of Alzheimer's Disease;Ruijin Hospital;School of Medicine;Shanghai Jiaotong University;Shanghai 200025;China); 作者单位 Author Agencies 上海交通大学医学院瑞金医院神经内科神经病学研究所上海阿尔茨海默病中心; 上海交通大学医学院瑞金医院神经内科神经病学研究所上海阿尔茨海默病中心 上海; 文献出处 Article From 上海交通大学学报(医学版);Journal of Shanghai Jiaotong University(Medical Science);2008年 05期; 关键词 (责任编辑:glia) |