Binhai Zheng, Ph.D.

CONTACT INFORMATION

Mailing address: Department of Neurosciences, University of California San Diego, 9500 Gilman Drive, MC 0691, La Jolla, CA 92093-0691

Phone: 858-534-5807

Fax: 858-822-1021

E-mail: binhai@ucsd.edu

EDUCATION AND EXPERIENCE

1988 – 1992 Fudan University, Shanghai, China

B. S. equivalent in Genetics and Genetic Engineering (1992)

1992 – 1994 School of Biological Sciences, University of Kentucky, Lexington, Kentucky

M.S. in Biology (1995)

Teaching assistant, Laboratory in Microbiology (9/1992 – 12/1993)

1994 – 1999 Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, Texas

Ph.D. in Molecular and Human Genetics (1999)

Thesis advisor: Dr. Allan Bradley

2000 – 2004 Department of Anatomy, and Howard Hughes Medical Institute, University of California at San Francisco; Department of Biological Sciences, and Howard Hughes Medical Institute, Stanford University, Stanford, California; Genentech, Inc., South San Francisco, California

Postdoctoral associate with Dr. Marc Tessier-Lavigne

2005 - present Department of Neurosciences, University of California - San Diego, School of Medicine, La Jolla, California

Assistant Professor (tenure-track)

AWARDS AND HONORS

1988-1991 University Scholarships, Fudan University

1994-1996 Cullen Foundation Predoctoral Fellowship, Baylor College of Medicine

1998 Outstanding Student Presentation Award, Department of Molecular and Human Genetics Annual Retreat, Baylor College of Medicine

1998 Selected as the department representative for platform presentation on the Annual Graduate Student Symposium, Baylor College of Medicine

2001-2004 Helen Hay Whitney Foundation Postdoctoral Fellowship

2005 The Ray Thomas Edwards Foundation Recognition Award

PUBLICATIONS

1. Roy, J., Zheng, B., Rymond, B. C., and Woolford, J. L., Jr. (1995). Structurally related but functionally distinct yeast Sm D core small nuclear ribonucleoprotein particle proteins. Mol. Cell. Biol. 15, 445-55.

2. Justice, M. J., Zheng, B., Woychik, R. P., and Bradley, A. (1997). Using targeted large deletions and high-efficiency N-ethyl-N- nitrosourea mutagenesis for functional analyses of the mammalian genome. Methods 13, 423-36.

3. Prolla, T. A., Baker, S. M., Harris, A. C., Tsao, J. L., Yao, X., Bronner, C. E., Zheng, B., Gordon, M., Reneker, J., Arnheim, N., Shibata, D., Bradley, A., and Liskay, R. M. (1998). Tumour susceptibility and spontaneous mutation in mice deficient in Mlh1, Pms1 and Pms2 DNA mismatch repair. Nat. Genet. 18, 276-9.

4. Bradley, A., Zheng, B., and Liu, P. (1998). Thirteen years of manipulating the mouse genome: a personal history. Int. J. Dev. Biol. 42, 943-50.

5. Seipelt, R. L., Zheng, B., Asuru, A., and Rymond, B. C. (1999). U1 snRNA is cleaved by RNase III and processed through an Sm site-dependent pathway. Nucleic Acids Res. 27, 587-95.

6. Mills, A. A., Zheng, B., Wang, X. J., Vogel, H., Roop, D. R., and Bradley, A. (1999). p63 is a p53 homologue required for limb and epidermal morphogenesis. Nature 398, 708-13.

7. Zheng, B., Mills, A. A., and Bradley, A. (1999). A system for rapid generation of coat color-tagged knockouts and defined chromosomal rearrangements in mice. Nucleic Acids Res. 27, 2354-60.

8. Zheng, B., Larkin, D. W., Albrecht, U., Sun, Z. S., Sage, M., Eichele, G., Lee, C. C., and Bradley, A. (1999). The mPer2 gene encodes a functional component of the mammalian circadian clock. Nature 400, 169-73.

9. Zheng, B., Sage, M., Cai, W. W., Thompson, D. M., Tavsanli, B. C., Cheah, Y. C., and Bradley, A. (1999). Engineering a mouse balancer chromosome. Nat. Genet. 22, 375-8.

10. Justice, M. J., Noveroske, J. K., Weber, J. S., Zheng, B., and Bradley, A. (1999). Mouse ENU mutagenesis. Hum. Mol. Genet. 8, 1955-63.

11. Zheng, B., Sage, M., Sheppeard, E. A., Jurecic, V., and Bradley, A. (2000). Engineering mouse chromosomes with Cre-loxP: range, efficiency, and somatic applications. Mol. Cell. Biol. 20, 648-55.

12. Shearman, L. P., Sriram, S., Weaver, D. R., Maywood, E. S., Chaves, I., Zheng, B., Kume, K., Lee, C. C., van der Horst, G. T., Hastings, M. H., and Reppert, S. M. (2000). Interacting molecular loops in the mammalian circadian clock. Science 288, 1013-9.

13. Albrecht, U., Zheng, B., Larkin, D., Sun, Z. S., and Lee, C. C. (2001). mPer1 and mPer2 are essential for normal resetting of the circadian clock. J. Biol. Rhythms 16, 100-4.

14. Zheng, B., Mills, A. A., and Bradley, A. (2001). Introducing defined chromosomal rearrangements into the mouse genome. Methods 24, 81-94.

15. Zheng, B., Albrecht, U., Kaasik, K., Sage, M., Lu, W., Vaishnav, S., Li, Q., Sun, Z. S., Eichele, G., Bradley, A., and Lee, C. C. (2001). Nonredundant roles of the mPer1 and mPer2 genes in the mammalian circadian clock. Cell 105, 683-94.

16. Cleary, M. A., van Raamsdonk, C. D., Levorse, J., Zheng, B., Bradley, A., and Tilghman, S. M. (2001). Disruption of an imprinted gene cluster by a targeted chromosomal translocation in mice. Nat. Genet. 29, 78-82.

17. Kopp, C., Albrecht, U., Zheng, B., and Tobler, I. (2002). Homeostatic sleep regulation is preserved in mPer1 and mPer2 mutant mice. Eur. J. Neurosci. 16, 1099-106.

18. Zheng, B., Vogel, H., Donehower, L. A., and Bradley, A. (2002). Visual genotyping of a coat color tagged p53 mutant mouse line. Cancer Biol. Ther. 1, 433-5.

19. Steward, O., Zheng, B., and Tessier-Lavigne, M. (2003). False resurrections: distinguishing regenerated from spared axons in the injured central nervous system. J. Comp. Neurol. 459, 1-8.

20. Zheng, B., Ho, C., Li, S., Keirstead, H., Steward, O., and Tessier-Lavigne, M. (2003). Lack of enhanced spinal regeneration in Nogo-deficient mice. Neuron 38, 213-24.

21. Steward, O., Zheng, B., Ho, C., Anderson, K., and Tessier-Lavigne, M. (2004). The dorsolateral corticospinal tract in mice: an alternative route for corticospinal input to caudal segments following dorsal column lesions. J. Comp. Neurol. 472, 463-77. (责任编辑：泉水)

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Binhai Zheng--神经生物学家介绍

CONTACT INFORMATION

18. Zheng, B., Vogel, H., Donehower, L. A., and Bradley, A. (2002). Visual genotyping of a coat color tagged p53 mutant mouse line. Cancer Biol. Ther. 1, 433-5.