BIOGRAPHICAL SKETCH
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| NAME Jian-wei Jiao
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POSITION TITLE Instructor
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DEGREE
(if applicable)
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YEAR(s) |
FIELD OF STUDY |
| Beijing University |
Ph.D |
1999-2002 |
Molecular Biology |
| Beijing University |
M.S |
1996-1999 |
Molecular Biology |
| Yantai University |
B.A |
1992-1996 |
Molecular Biology |
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A. Positions and Honors.
Positions and Employment 2008- Instructor (pending) Harvard Medical School 2007- Research Associate Harvard Medical School, Schepens Eye Research Institute 2002-2007 Postdoctoral fellow Harvard Medical School, Schepens Eye Research Institute
Other Experience and Professional Memberships
2005- Member, Harvard Center for Neurodegeneration & Repair
2003- Member, International Society for Stem Cell Research
2003- Member, The Association of Research in Vision and Ophthalmology
2002- Member, Society for Neuroscience
Honors
2008 National Institute of Health (NIH) travel Award (ARVO) 2002 Distinguished PH.D graduate student 2001 Novo Nordisk Scholarship 2001 Ten Academically Outstanding Students
B. Selected peer-reviewed publications (in chronological order).
1. Jiao J & Chen DF. Ephrins as negative regulators of adult neurogenesis in diverse regions of the central nervous system. PNAS, 2008 (in press) 2. Jiao J & Chen DF. Induction of neurogenesis in non-conventional neurogenic regions of the adult CNS by niche Astrocyte-produced signals, Stem Cells, 2008 (stem cell express, in press) 3. Jiao J, Chen DF & Darlen DA. Wnt regulates neural stem cell proliferation through Ca2+, PKC and MAPK pathway. 2008 (submitted) 4. Jiao J & Chen DF. FGF15 control neurogenesis and gliogenesis during brain development. 2008 (in prepartion) 5. Takeda M, Takamiya A, Jiao J, Cho KS, Trevino SG, Matsuda T & Chen DF. Alpha-aminoadipate induces progenitor cell properties of Muller glia in adult mice. IOVS, 2008, 49(3):1142-1150 6. Nakazawa T, Takeda M, Lewis GP, Cho KS, Jiao J, Wilhelmsson U, Fisher SK, Pekny M, Chen DF, Miller JW. Attenuated glial reactions and photoreceptor degeneration after retinal detachment in mice deficient glial fibrillary acidic protein and vimentin. IOVS, 2007, 48:2760-2768. 7. Jiao J, Huang X, Feit-Leithman RA, Neve RL, Snider W, Dartt DA & Chen DF. Bcl-2 enhances Ca2+ signaling to support the intrinsic regenerative capacity of CNS axons. EMBO J, 2005, 24: 1068-1078 8. Zhang L, Jiao J, Shao K, Yu M & Ru b. Simulation, construction and expression of the recombinant dscuPA with thrombolytic and antithrombus bifunction. Chem J Chin Univ, 2004, 25 (6): 1046-1050 9. Jiao J & Ru B. Advances on the thrombolytic agents research. Prog Biotech, 2002, 18 (1): 30-32. 10. Jiao J, Yu M & Ru B. Construction and characterization of a recombinant chimeric plasminogen activator consisting of a fibrin peptide and a low molecular mass single-chain urokinase. Biochimie, 2001, 83:1049-1055 11. Jiao J, Yu M & Ru B. Characterization of a recombinant chimeric plasminogen activator with enhanced fibrin binding. Biochim Biophys Acta, 2001, 1546 (2): 399-405 12. Jiao J, Liu N, Yu M & Ru B. Construction and expression of a fusion protein with fibrin peptide and scuPA-32k. Prog Biochem Biophys, 2001, 28 (6): 861-864 13. Jiao J, Yu M & Ru B. Application of a gel chromatography renaturing way on low molecular single-Chain urokinase mutant (DscuPA-32k). Chin J Biotech, 2001, 17 (3): 300-303 14. Jiao J, Ru Q, Yu M & Ru B. Construction and characterization of the chimeric protein consisting RGD-containing peptide and proUK. Chin J Biotech, 2001, 17 (5): 531-533 15. Jiao J, Yu M & Ru B. High expression of an eukaryotic scuPA-32K mutant gene in E. Coli. Chin J Biochem Mol Biol, 2001, 17 (3): 340-343 14. Jiao J, Zhang L, Yu M & Ru B. Cloning and expression of an antithrombolytic peptide—Decorsin. Chin J Biochem Mol Biol, 2001, 17 (5): 602-605 15. Jiao J & Xu C. Construction and expression of GHRP-scu-PA-32K. Acta Sci Natur Univ Pekinensis, 2000, 36 (2): 203-208
II. Conference publication 1. Jiao J, Feldheim DA, & Chen DF. Ephrins are key components of a prohibitive niche for neurogenesis in the adult central nervous system. SOCIETY FOR NEUROSCIENCE 2006 2. Jiao J & Chen DF. Astroglia serving as a source of neural stem cells outside of neurogenetic areas of the adult CNS. SOCIETY FOR NEUROSCIENCE. 2005 3. Jiao J. Isolation neural progenitor cells from subcortical but not cerebellum white matter of adult brain. INTERNATIONAL SOCIETY FOR STEM CELL RESEARCH. 2005 4. Takeda M, Jiao J, Cho KS & Chen DF. Glutamate stimulates neurogenesis and photoreceptor cell regeneration in the adult mouse retina. ASSOCIATION FOR RESEARCH IN VISION AND OPHTHALMOLOGY. 2005 5. Jiao J, Huang X, Feit R, Snider W, Dartt D, Chen D. BCL - 2 signaling Ca2+ to promote the intrinsic regenerative capacity of CNS axons. SOCIETY FOR NEUROSCIENCE. 2004 6. Jiao J. Signaling pathway for Bcl-2 to promote differentiation and regeneration. SCHEPENS EYE RESEARCH INSTITUTE, 2004 7. Yang L, Jiao J & Chen DF. Neuroprotective effect of lithium on retinal detachment-associated photoreceptor cell degeneration. ASSOCIATION FOR RESEARCH IN VISION AND OPHTHALMOLOGY. 2004 8. Jiao J, Huang X & Chen DF. Distinctive roles of Bcl-2 and Bcl-xL in regulating neuronal survival and neurite outgrowth. SOCIETY FOR NEUROSCIENCE. 2003
C. Research Interest
1. Inducing human adult fibroblast cells to become embryonic stem cells 2. Finding the source of neural stem cells from adult brain 3. Uncovering the inhibitors that prohibit adult neural stem cells proliferation 4. Investigating neural stem cells and their niches 5. Studying Sonic Hedgehog and Wnt in the neural stem cell proliferation 6. Studying the mechanisms that control neurogenesis in embryonic brain development
D. Report of Teaching or Instructing Students
2006, Jason Debasitis, Undergraduate Student of Harvard College, Harvard Stem Cell Institute Summer Research Program 2005, Serena Rezny, Undergraduate Student of Harvard College, Harvard Stem Cell Institute Summer Research Program 2004, Simon Trevino, Undergraduate Student of University of Texas at San Antonio, Harvard Medical School selected National Students for Summer Research
E. Reviewership
1. Nature Neuroscience 2. Brain Research Bulletin 3. Experimental Eye Research 4. Neuroscience Letters
F. References
1. Dong Feng Chen Associate Scientist, Assitant Professor Schepens Eye Research Institute, Harvard Medical School, Tel: (1) 617-912-7490, Email: dongfengchen@schepens.harvard.edu 2. Darlene A. Dartt Senior Scientist, Associate Professor, Director of Scientific Affairs, Schepens Eye Research Institute, Harvard Medical School Tel: (1) 617-912-0272, Email: darlene.dartt@schepens.harvard.edu 3. Andrius Kazlauskas Senior Scientist, Associate Professor Schepens Eye Research Institute, Harvard Medical School Tel: (1) 617-912-2517, Email: andrius.kazlauskas@schepens.harvard.edu 4. Tiansen Li Associate Professor Mass Eye and Ear infirmary, Harvard medical School, Email: tli@meei.harvard.edu
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