Fu-De Huang, Ph.D.　Associate Investigator

Name: Fu-De Huang

Education:

1992, Bachelor degree in Medicine, Nanhua University (

China

). 1997, Master degree in Neurobiology, Shanghai Brain Research Institute, Chinese Academy of Sciences (China). 1999, Master degree in Neurobiology, Singapore National University (

Singapore

). 2006, Ph.D in Biological Sciences, Vanderbilt University (USA), “GPA=4.00”.

Work experience:

1992-1994, resident physician, People’s Hospital of Ruchen County, Hunan province (China) 2006-current, Associate Investigator of Neural Plasticity Lab, Institute of Neuroscience, Chinese Academy of Sciences

Research skills:

1. Extracellular and intracellular (current- and voltage-clamp) electrical recordings in monkeys, rats, flies and Xenopus oocytes. 2. Fly genetics, especially transposon-mediated mutagenesis and identification of mutant genes. 3. Generation of transgenic flies and C. elegans. 4. Molecular biology, have subcloned over 10 different recombinant DNAs of 5 genes into 6 different plasmids. 5. Biochemistry, immunoprecepitation and western blot, general lipase activity examination. 6. Histology, immunostaining on rat and Drosophila preparations.

Research interests:

1. The mechanisms of presynaptic vesicle cycling, the modulation/regulation of synaptic receptor function, synaptic changes in Alzheimer’s disease. 2. Neurogenesis in Drosophila. 3. The mechanism of Drosophila phototransduction.

Presentations:

Oral presentations: 1. International Annual Neuroscience Meeting at New Orleans (USA) in 2003. 2. Neurobiology of Drosophila at Cold Spring Harbor Laboratory (USA) in 2005.

Poster presentations: 1. International Annual Neuroscience Meeting at Miami (USA) in 1999. 2. Neurobiology of Drosophila at Cold Spring Harbor Laboratory (USA) in 2001. 3. International Annual Neuroscience Meeting at Orlando (USA) in 2002.

Selected Publications:

1. Zhao X, Tan JX, Wang YH, Poo MM* and Huang FD*. Beta-amyloid induced age-dependent changes in presynaptic function and structure in Drosophila. In preparation.

2. Yu Y, Xu C, Huang FD, Chen N*, et al. Clinical and electrophysiological characterization of the CLCNKB gene novel mutations in Chinese patients with classic Bartter Syndrome. In preparation.

3. Huang FD, Woodruff E, Mohrmann R, and Broadie K* (2006). Rolling Blackout is required for synaptic vesicle exocytosis in Drosophila. J. Neurosci. 26(9):2369-79

4. Tai SK, Huang FD, Moochhala S, and Khanna, S* (2006). Hipp.ocampal theta state in relation to formalin nociception. Pain, 121 (1-2):29-42.

5. Huang FD, Matthies HJ, Speese SD, Smith MA, and Broadie K.* (2004). Rolling blackout, a newly identified PIP2-DAG pathway lipase required for Drosophila phototransduction. Nat. Neurosci. 7, 1070-1078. 6. Huang FD, Chen J, Lin M, Keating MT, Sanguinetti MC*. (2001). Long-QT syndrome-associated missense mutations in the pore helix of the HERG potassium channel. Circulation 104, 1071-1075.

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