两澳大利亚人获诺贝尔医学奖(5)

An  indiscriminate  use  of  antibiotics  to  eradicate  Helicobacter  pylori  also  from  healthy  carriers  would  lead  to  severe  problems  with  bacterial  resistance  against  these  important  drugs.  Therefore,  treatment  against  Helicobacter  pylori  should  be  used  restrictively  in  patients  without  documented  gastric  or  duodenal  ulcer  disease.

Microbial  origin  of  other  chronic  inflammatory  conditions?

Many  diseases  in  humans  such  as  Crohn's  disease,  ulcerative  colitis,  rheumatoid  arthritis  and  atherosclerosis  are  due  to  chronic  inflammation.  The  discovery  that  one  of  the  most  common  diseases  of  mankind,  peptic  ulcer  disease,  has  a  microbial  cause,  has  stimulated  the  search  for  microbes  as  possible  causes  of  other  chronic  inflammatory  conditions.

Even  though  no  definite  answers  are  at  hand,  recent  data  clearly  suggest  that  a  dysfunction  in  the  recognition  of  microbial  products  by  the  human  immune  system  can  result  in  disease  development.  The  discovery  of  Helicobacter  pylori  has  led  to  an  increased  understanding  of  the  connection  between  chronic  infection,  inflammation  and  cancer. (责任编辑：泉水)

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两澳大利亚人获诺贝尔医学奖(5)