Ron Stoop--蒲慕明教授的学生

Curriculum Vitae
Ron Stoop

Dr. Ron Stoop received his undergraduate training at Nymegen University in the Netherlands in 1987. He subsequently worked for several years in China as scholar and visiting scientist at the Chinese Academy of Sciences and at Tsinghua University before joining Dr. Muming Poo's laboratory at Columbia University for his graduate studies in 1991. He obtained his Ph.D. degree in 1996. After a postdoctoral research training in industry at Glaxo-Welcome Biomedical Research Institute in Geneva (1996-1998) and a first assistant-ship within the Medical Faculty of the University of Lausanne (Department of Cellular Biology and Morphology, 1998-2003), he joined the Centre for Psychiatric Neuroscience as a group leader in 2004.

The Centre for Psychiatric Neuroscience (CNP) has been established in 2002 in a joint effort between the University of Lausanne, the University Hospital of Lausanne (CHUV or Centre Hospitalier Universitaire Vaudois) and the Polytechnical Highschool of Lausanne (EPFL). It accommodates basic neuroscientists with a strong interest in translational neuroscience towards neuropsychiatric diseases. The CNP is situated within the psychiatric hospital community of Cery, located within surroundings of forest and rural landscape at a short distance north of Lausanne. In this unique research setting, neuroscientists and neuropsychiatrists interact on a daily basis to gain deeper understanding into the basic biological mechanisms that may underlie a large range of neuropsychiatric illnesses (see website Cery).

Dr. Stoop's research focuses on the measurement of electrophysiological signaling between hippocampus - amygdala and the output to and interactions of this latter nucleus with the brainstem. To this purpose he uses a newly developed in vitro horizontal slice preparation of the rodent limbic system that includes hippocampus, entorhinal cortex and amygdala and intact connections between these structures (Stoop et al., Eur. J. Neurosci 2000). Measuring methods include extra,- intra,- and whole-cell patch-clamp electrophysiological recording techniques in combination with histological analysis as well as fluorescent imaging and latest molecular biological approaches. Recent findings include the rapid development of persistent epileptiform bursting following short exposures of these slice preparation to the GABA(A) receptor inhibitor bicuculline (Stoop et al., J. Neursci, 2003) and the modulatory effects of oxytocin and vasopressin on the processing of information within the output center of the amygdala (Huber et al., Science, 2005).

For further information please contact rstoop@unil.ch

Publications:

D. Huber, P. Veinante and R. Stoop. Vasopressin and Oxytocin Excite Distinct Neuronal Populations in the Central Amygdala. Science, 308: 245-248, 2005.

R. Stoop, F. Conquet, B. Zuber, L.L. Voronin, and E. Pralong. Transient CA3 Epileptiform Activity Induces Persistent Bursting and Concerted, mGluR5 Mediated Changes in Synaptic Strength. Journal of Neuroscience, 23(13):5634-44 (2003).

R. Stoop, F. Conquet and E. Pralong Determination of group I metabotropic glutamate receptor subtypes involved in the patterning of epileptiform activity in vitro using mGluR1 and mGluR5 mutant mice. Neuropharmacology 44:157-62 (2003).

E. Pralong, P. Magistretti, R. Stoop. Cellular perspectives on the glutamate-monoamine interactions in the limbic cortex and their relevance for some psychiatric disorders. Progress in Neurobiology 67: 173-202 (2002).

R. Stoop and E. Pralong. Functional connections and epileptic spread between hippocampus, entorhinal cortex and amygdala in a modified horizontal slice preparation of the rat brain. European Journal of Neuroscience 12(10):3651-63 (2000).

R. Stoop, S. Epiney, E. Meier and E. Pralong. Modulation of epileptic discharges in the rat limbic system in vitro by noradrenergic agents. Neuroscience Letters 287:5-8 (2000).

R. Stoop, S. Thomas, F.A. Rassendren, G. Buell, A.S. Surprenant and R.A. North. Contribution of individual subunits to the multimeric P2X2 receptor: Estimates based on Methanethiosulphonate block at T336C. Molecular Pharmacology 56:973-981(1999).

R. Stoop and J.M. Quayle. Fading and rebound of P2X2 currents at millimolar ATP concentrations caused by low pH. British Journal of Pharmacology 125:235-237 (1998).

A. Newbolt, R. Stoop, C. Virginio, A.S. Surprenant, R.A. North and F.A. Rassendren. Membrane topology of P2X2 receptor. Journal of Biological Chemistry 273:15177-15182 (1998).

R. Stoop, A.S. Surprenant and R. A. North. Different sensitivities to pH of ATP-induced currents at four cloned P2X receptors. Journal of Neurophysiology 78(4):1837-1840 (1997).

R. Stoop and M.-m. Poo. Synaptic modulation by neurotrophic factors. Progress in Brain Research 109:359-64 (1996).

R. Stoop and M.-m. Poo. Synaptic modulation by neurotrophic factors: differential and synergistic effects of BDNF and CNTF. Journal of Neuroscience 16(10):3256-3264 (1996).

R. Stoop and M.-m. Poo. Potentiation of transmitter release by ciliary neurotrophic factor requires somatic signaling. Science 267:695-699 (1995).

Z.P. Xie, Y.G. Tang, R. Stoop, J. Mao, N.M. Zhao, C.N. Lu, S.R. Yang, X.P. He and C.G. Liu. The effects of glutamate and GABA (gamma-amino-butyric acid) on spontaneous acetylcholine release at the neuromuscular junction in Xenopus laevis embryo cell cultures. Science in China, Series B, Chemistry, Life Sciences and Earth Sciences 36(9):1110-1116 (1993). c

C.L. Zhao, R. Stoop, C.G. Liu, X.P. He and Z.P. Xie. Blocking effects of anisodamine on cetylcholine receptor channels. Acta Pharmacologica Sinica (Chung-Kuo Yao Li Hsueh Pao) 14(2):190-192 (1993).

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Ron Stoop--蒲慕明教授的学生