2. Regional, national, or international contributions:
Invited Lectures: Asilomar Converence: Neuronal Plasticity and repair 1996.
University of Cincinnati 1997
American Academy of Neurology Faculty (1997,1998,1999)
Gordon Conference "Neurotrophic Factors1997
Case Western Reserve University 1998
Uniform Health Services University
1998 Brandeis University
1999 Children's Hospital
1999 American Society for Neurochemistry
2000 Johns Hopkins University
1999 University of Massachusetts Medical Center
2000 Mount Sinai Medical Center
2000 Gordon Conference "Cell Biology of the Neuron"
2000 Wood's Hole Marine Biology Laboratory, Course in Neurobiology
2000 Columbia University Medical School 2001

Patent Information:
Patent application number: PCT/US99/02871 NT3 in Medulloblastoma

PART III: Bibliography
Original Reports:
1. Krueger J, Segal RA, Moyers R. 1977. Differences in the responsiveness of splenic, lymph node and peripheral blood lymphoid cells to tumor membrane extracts. Cancer Res. 37: 320-322.

2.Chen LB, Murray A, Segal RA, Buchnell A, Walsh ML. 1978. Studies on intracellular LETS glycoprotein matrices. Cell 14: 377-391.

3. Hsieh P, Segal RA, Chen LB. 1980. Studies of fibronectin matrices in living cells with fluoroscinated gelatin. J. Cell Biol. 87: 14-22.

4. Segal RA, Huang B, Ramanis Z, Luck DJL. 1984. Mutant strains of Chlamydomonas reinhardtii that move backwards only. J. Cell Biol. 1984; 98: 2026-2034.

5. Segal RA, Luck DJL. 1985. Phosphorylation in isolated Chlamydomonas axonemes: A phosphoprotein may mediate the Ca+2-dependent photophobic response. J. Cell Biol. 101: 1702-1712.

6. Segal RA, Chapman C, Barlow J. 1991. Monozygotic twins with seizures: shared characteristics. Arch. Neurol. 48: 1041-1048.

7. Segal RA, Takahashi H, McKay R. 1992. Changes in neurotrophin responsiveness during the development of cerebellar granule neurons. Neuron 1992; 9: 1041-1052.

8. Segal RA, Goumnerova LC, Kwon YK, CD Stiles CD, Pomeroy SL. 1994. Expression of the neurotrophin receptor trkC is linked to a favorable outcome in medulloblastoma. Proc. Nat. Acad. Sci. USA. 1994; 91: 12867-12871.

9. Segal RA, Pomeroy SL, Stiles CD. 1995. Axonal growth and fasciculation linked to differential expression of BDNF and NT3 receptors in developing cerebellar granule cells. J. Neurosci. 15: 4970-4981.

10. Segal RA, Bhattacharyya A, Rua L, Alberta JA, Stephens RM, Kaplan DR, Stiles CD. 1996. Differential utilization of Trk autophosphorylation sites in vivo. J. Biol. Chem. 271:20175-20181.

11. Nachmanoff D, Segal RA, Brown RB, De Girolami U, Dawson DM. Hereditary ataxia with sensory neuronopathy: Biemond's ataxia. Neurology, 1997; 48:273-275.

12. Dudek H, Datta SR, Franke TF, Birnbaum MJ, Yao R, Cooper GM, Segal RA, Kaplan DR, Greenberg ME. 1997. Regulation of neuronal survival by the ser/thr protein kinase Akt. Science, 1997; 275: 661-665.

13. Cabelli RJ, Shelton D, Segal RA, Shatz CJ. 1997. An endogenous ligand of TrkB is required for ocular dominance segregation. Neuron 19: 63-76.

14. Schwartz PM, Borghesani, Levy RL, Pomeroy SL, Segal RA. 1997. Abnormal cerebellar development and foliation in BDNF -/- mice reveals a role for neurotrophins in CNS patterning. Neuron 19: 269-281

15. Bhattacharyya A, Watson FL, Bradlee TA, Pomeroy SL, Stiles CD, Segal RA. 1997. Trk receptors function as retrograde signal carriers in the adult nervous system. J. Neurosci., 17:7007-7016.

16. Schwartz PM, Borghesani PR, Levy RL, Segal RA. 1998. Cerebellar pathology in BDNF -/- mice: The classic view of neurotrophins is changing. Molecular Psychiatry, 3: 116-118.

17. Ma Q, Jones D, Borghesani PR, Segal RA, Nagasawa T, Kishimoto T, Bronson, RT, Springer TA. 1998. Impaired B-Lymphopoiesis, myelopoiesis and derailed cerebellar neuron migration in CXCR4 and SDF-1 deficient mice. Proc. Nat.Acad. Sci. USA. 95: 9448-53.

18. Kim J, Sutton ME, Lu DJ, Cho TA, Goumnerova LC, Goritchenko L, Lam KK, Allen JC, Wu J, Tarbell NJ, Billett AL, Segal RA, Pomeroy SL. 1999. High NT-3 receptor expression and apoptosis in favorable medulloblastomas. Cancer Research 59: 711-719.

19. Watson FL, Porcionatto MA, Bhattacharyya A, Stiles CD, Segal RA. 1999. TrkA Glycosylation regulates receptor localization and activity. J. Neurobiology, 39:323-336.

20. Watson FL, Heersson HM, Moheban DB, Lin MZ, Sauvageot CM, Pomeroy SL, Bhattacharyya A, Segal RA. 1999. Rapid nuclear responses to target derived neurotrophins require retrograde transport of ligand-receptor complex. J. Neurosci. 19:7889-7900.

21. Borghesani PR , Alt FW, Bottaro A, Davidson L, Aksoy S, Rathbun GA, Roberts TM, Swat W, Segal RA, Gu Y. 2000. Abnormal Development of Purkinje Cells and Lymphocytes in Atm Mutant Mice. Proc. Nat. Acad. Sci. USA, 97(7):3336-41.

22. Zhang YZ, Moheban DB,. Conway BR, Bhattacharyya A, Segal RA. 2000. Cell surface Trk receptors mediate NGF-induced survival while internalized receptors regulate NGF-induced differentiation. J. Neurosci, 20, 5671-5678.

23. O'Brien SP, Seipel K, Medley QG, Bronson R, Segal R, Streuli M. 2000. Skeletal muscle deformity and neuronal disorder in Trio exchange factor-deficient mouse embryos. Proc Natl Acad Sci U S A ;97(22):12074-12078.

24. Deog-Young Choi, Juan J Toledo-Aral, Rosalind A. Segal, Simon Halegoua. Sustained signaling by PLCg mediates NGF-triggered gene expression. Mol. Cell Biol., in press.

25. Robyn S. Klein, Joshua B. Rubin=, Hilary D. Gibson, Elliot N. DeHaan, Xavier Alvarez-Hernandez, Rosalind A. Segal, and Andrew D. Luster. SDF-1a induces chemotaxis and enhances Sonic hedgehog-induced proliferation of cerebellar granule cells. Development, in press.

26. Paul R. Borghesani, Jean Michel Peyrin, Joshua Rubin, Alexandre R. Carter, Phillip M. Schwartz, Li-Hue Tsai, Gabriel Corfas, Rosalind A. Segal. Neuronal migration promotes cell cycle exit. Neuron, revised manuscript submitted.

Reviews and Book Chapters:
1. Segal RA and Greenberg ME. 1996. Intracellular signaling pathways activated by neurotrophic factors. Annu. Rev. Neurosci. 19: 463-489

2. Segal RA, Rua L , Schwartz P. 1997. Neurotrophins and programmed cell death during cerebellar development. Advances in Neurology vol 72, Chapter 8.

3. Pomeroy SL and Segal RA. "Development of the Nervous System" in Neonatal and Fetal Medicine , Poland RA and Fox WW eds. Philadelphia, Saunders.

4. Pomeroy SL, Sutton ME, Goumenrova LC, Segal RA. 1997. Neurotrophins in cerebellar granule cell development and medulloblastoma. J.Neuro-Oncology , 35: 347-352.

6. Alberta JA and Segal RA. Current Protocols in Neuroscience Unit 3.6 Generation and utilization of phosphorylation-state specific antibodies to investigate neuronal signaling pathways.

7. Alexandre R. Carter and Rosalind A. Segal. Rett syndrome suggests methyl-CpG binding protein 2 provides neurons with the quiet they need to think. Nature Neuroscience, in press.

Abstracts:
SL Pomeroy, LC Goumnerova, YK Kwon, CD Stiles, RA Segal. Coordinate expression of neurotrophin-3 and TrkC linked to a more favorable prognosis in medulloblastoma. 1994. Soc. Neurosci. Abstr. Vol 20, Part 2, p. 1105.

A Bhattacharyya, L Rua, DR Kaplan, CD Stiles, RA Segal. Generation of antibodies to activated Trk receptors. 1994 Soc. Neurosci. Abstr. Vol 20, Part 1, p. 38.

PM Schwartz, PR Borghesani, RL Levy, RA Segal. 1997. Abnormal cerebellar development and foliation in BDNF -/- mice reveals a role for neurotrophins in CNS patterning. Soc. Neurosci. Abstr. Vol 23, part 1, p. 59.

A Bhattacharyya, FL Watson, TA Bradlee, SL Pomeroy, CD Stiles, RA Segal. 1997. Trk receptors function as rapid retrograde signal carriers in the adult nervous system. Soc. Neurosci. Abstr. Vol 23, part 2, p.1433.